Nearly 60 years ago Toronto physician William McCormick observed that cancer patients often presented with severely low levels of vitamin C in their blood and featured scurvy-like symptoms, leading him to postulate that vitamin C might protect against cancer by increasing collagen synthesis
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The randomization sequence was kept in a sealed, opaque envelope, which was opened sequentially by the recruiting team upon patient enrollment
doi: 10.1002/jlb.56.5.559
Oxidative stress in Alzheimer disease: a possibility for prevention
Vitamin C also plays an important role in collagen production, which affects the integrity of skin, blood vessels, cartilage, and connective tissues